It's Garry Shandling's Show

Garry Shandling stars in this sitcom as, more or less, himself – a neurotic, slightly self-obsessed, stand-up comedian.

He interacts with the audience as well as the cast members. Garry and the supporting characters know they are on a TV show, and the studio audience is often a part of the storyline. Shandling often manipulates storylines to make them more entertaining.