Chaotic comedy. Newlyweds Carl and Molly are settling in to enjoy their lives together when their marital bliss is shattered by the arrival of Carl's freewheeling best friend Dupree. Dupree lost his job and his home for attending their wedding, and Carl agrees to let him stay in their house until he gets back on his feet. But neither Carl nor Molly expect the trail of havoc that follows in Dupree's wake.