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At the center of the story is state judge Robert Lewis (Michael Douglas) who has been appointed by the president to spearhead America's escalating war against drugs and has now become the USA's newest drug czar.
What he doesn't know, however, is that the drug war extends into even his own home, as his teenage daughter (Erika Christensen) is addicted to crack and heroin, introduced to this dark world of drugs by her boyfriend, Seth Abrahams (Topher Grace).
Helen Montoya (Catherine Zeta-Jones), is a former housewife turned drug smuggler who is being represented by her lawyer, Arnie Metzger (Dennis Quaid).