Jude Law, Rooney Mara, Channing Tatum and Catherine Zeta-Jones star in Steven Soderbergh's dark psychological thriller about big pharma, prescription medicines and psychiatry.
Forced to face up to her reduced circumstances, Emily Taylor's depression intensifies when her husband Martin is released from prison after four years' incarceration for insider dealing.
Emily becomes a patient of Dr Jonathan Banks after her involvement in a car crash is interpreted as an attempt at self-harm; and he prescribes an experimental anti-depressant following a further incident and a conversation with her former psychiatrist. At first the drug seems to produce perfect results. But then the side effects kick in, and their consequences are terrible for all involved.
As Banks's feelings morph from remorse to suspicion, he turns amateur sleuth - and discovers there's more to the case than meets the eye.