This romantic comedy, is about Bob Rueland (David Duchovny) who is a big Chicago building contractor.
He and his wife, Elizabeth (Joely Richardson), a vet, are very much in love and happily married. Until, that is, she is fatally injured in a car accident.
Bob is now given the heart breaking decision whether or not to donate her organs for transplantation as she is not going to survive the trauma her body has endured.
Meanwhile across the city, Grace Briggs (Minnie Driver), an Italian restaurant waitress, and her family receive some wonderful news... a heart has finally been found for Grace's much needed heart transplant. The heart, as if you hadn't guessed, belongs to the near-late Elizabeth Rueland.
Both Bob and Grace struggle to come to terms with their changing lives and try to maintain as much a normal life as possible until, that is, they meet.
Now Bob must decide which of the women actually holds his heart.