With the world over-run by slavering zombie types, Alice (Milla Jovovich) continues her search for fellow survivors, discovering an emergency broadcast from a safe haven in Alaska called Arcadia. Bumping into old pal Claire (Ali Larter), who is under the control of the evil Umbrella Corporation, Alice manages to save her and the two head for Alaska in a small plane.
Experiencing troubles over Los Angeles, Alice is forced to crash on the roof of a high-security prison where they meet a group of survivors. Among them are leader Luther West (Boris Kodjoe), egotistical Hollywood producer Bennett (Kim Coates), and inmate Chris (Wentworth Miller).
With the prison surrounded by flesh-chomping maniacs, not to mention a monstrous axe-wielding creature, it's only a matter of time before the ghouls break in, but the plane is too small to get everyone out. Can Alice and co band together and find a way to Arcadia, or is this the last stand for humanity?
As this convoluted synopsis proves, the plot of Resident Evil: Afterlife is hardly its strong point.
Fortunately, Anderson, who returns for this fourth instalment after directing the first, has the good sense to throw in wall-to-wall action sequences and plenty of bloody zombie takedowns.