Two Los Angeles friends, and renowned former professional boxers, named Cesar Dominguez (Antonio Banderas) and Vince Boudreau (Woody Harrelson), are in Los Angeles when they get a call from a Las Vegas promoter because his undercard fighters for his high profile arranged Mike Tyson bout that night are suddenly unavailable.
Now the promoter wants them to box each other. The two agree as long as the winner gets a shot at the middleweight title for the next season. They enlist Grace Pasic (Lolita Davidovich), Cesar's current girlfriend (who once went with Vince too), to drive them to Vegas.
On the trip, we get to see flashbacks of their previous title shots, their ever-competitive friendship, and Gloria's motivational wiles. (She has her own entrepreneurial dreams.)
The fight itself is nothing short of historic: ten rounds of savagery and courage. Who will win, who'll get the title shot, who gets Gloria, and where will she find venture capital.