Nutty Professor II: The Klumps (2000)

Professor Sherman Klump (Eddie Murphy) is getting married in this hilarious sequel and the Klump family could not be more delighted for him, of course.

However Buddy Love, his Mr. Hyde alter-ego from the first film, is back and trying to make it on his own. Sherman decides to rid himself of his monstrous nemesis - and his disruptive outbursts - once and for all by extracting Buddy's DNA from his system. But Buddy bursts full-bodied into Sherman's world and lays claim to the professor's astounding invention - a revolutionary youth serum.

Desperate to keep it from Buddy, Sherman hides the serum in the Klump family home, thinking it will be safe. Buddy correctly divines where Sherman has placed the serum, but to get it, he has to deal with the entire Klump family first. The family consist of Cletus "Papa" Klump, Young Cletus Klump, Anna "Mama" Klump, Ernie Klump & Grandpa Klump (all of whom are played by the talented Eddie Murphy).

All mayhem breaks loose as you can imagine. Very funny, a must see if you liked the first one.