Charlie has a gift which becomes a curse. Every woman who sleeps with him immediately meets her perfect Mr Right after their encounter - which means a lot of women in line for him, making a satisfying, if lonely, life for Chuck. Then he meets Cam Wexler, the perfect girl for him. But if he sleeps with her, he'll lose her. It's up to Charlie and his best friend Stu to come up with a plan in Mark Helfrich's comedy.