Tim Story's action fantasy stars Ioan Gruffudd, Michael Chiklis, Jessica Alba and Chris Evans as Reed Richards, Ben Grimm, Sue Storm and Johnny Storm, four astronauts sent to investigate a cosmic radiation storm.
They get caught by the storm's effects before they can erect safety shields. Each of them finds their bodies changed to superhuman effect: Richards becomes the super-elastic Mr Fantastic; Grimm, the super strong Thing; Sue, the Invisible Woman; and Johnny, the Human Torch.
At first they revel in their powers to prevent death and disaster, but they are soon drawn into battle with Victor von Doom. He was once the sponsor of their experiments and space exploration, but exposure to the same radiation storm transformed him into Dr Doom, a metallic creature who can manipulate electricity and wants to use his power to destroy the Fantastic Four and rule the world.